Oxiconazole

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Oxiconazole

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

64211-45-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

奥昔康唑
Ro 13-8996 free base

产品介绍

Oxiconazole (Ro 13-8996) 是一种广谱抗真菌剂，能抑制念珠菌 (Candida)、曲霉属真菌 (Aspergillus) 和毛癣菌属真菌 (Trichophyton) 的生长。Oxiconazole 也是一种高效的CYP3A4反式激活剂，可与利福平 (Rifampicin; HY-B0272) 竞争性拮抗。Oxiconazole 通过过氧化物酶 2 (PRDX2) 介导的细胞自噬 (autophagy) 停滞来发挥抗结直肠癌的作用。

生物活性

Oxiconazole (Ro 13-8996) is a broad spectrum anti-fungalagent which can inhibit the growth ofCandida,AspergillusandTrichophyton. Oxiconazole is also a highly efficacious activator ofCYP3A4transactivation, which could be antagonized byRifampicin(HY-B0272) in a competitive manner. Oxiconazole exhibits inhibitory effect against colorectalcancer(CRC) via peroxiredoxin-2 (PRDX2)-mediatedautophagyarrest^[1]^[2]^[3].

IC₅₀& Target^[2]

CYP3A4

体外研究
(In Vitro)

Oxiconazole (24 h; 0-40 μM) inhibits CRC cell growth^[3].
Oxiconazole has antifungal activity againstCandida,AspergillusandTrichophyton^[1].
Antifungal Activities of Oxiconazole^[1].

	Candida albicans	Candida glabrata	Candida parapsilosis	Aspergillus fumigatus	Aspergillus flavus	Trichophyton mentagrophytes	Trichophyton rubrum
Oxiconazole	0.03 μg/mL	0.01 μg/mL	0.008 μg/mL	2 μg/mL	2 μg/mL	2 μg/mL	2 μg/mL

Cell Proliferation Assay^[3]

Cell Line:	HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460
Concentration:	0-40 μM
Incubation Time:	24 h
Result:	Exhibited inhibitory activity against HCT116, SW480, RKO, DLD-1, SW620, LoVo and NCM460 with IC₅₀s of 25.86 μM, 27.34 μM, 21.01 μM, 25.56 μM, 21.75 μM, 24.87 μM and 126.4 μM.

体内研究
(In Vivo)

Oxiconazole (50 mg/kg/day; IP; for 12 days) significantly restrains CRC cell growth^[3].

Animal Model:	BALB/c nude mice (injected subcutaneously with HCT116 cells (1×10⁷/mouse)^[3]
Dosage:	50 mg/kg/day
Administration:	IP; for 12 days
Result:	Significantly restrained CRC cell growth and showed no obvious side effects.

Clinical Trial

分子量

429.13

Formula

C₁₈H₁₃Cl₄N₃O

CAS 号

64211-45-6

中文名称

奥昔康唑

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.