ML204 hydrochloride is a novel, potent, selectiveTRPC4/TRPC5channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca²⁺channels^[1][2].

ML204 hydrochloride inhibits TRPC4β-mediated intracellular Ca²⁺rise with an IC₅₀value of 0.96 μM (HEK293 cells) and exhibits 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation^[1].
ML204 hydrochloride blocks TRPC4β activity induced through either G_i/ostimulation by μ-opioid, 5HT_1Aserotonin, and M₂muscarinic receptors or G_q/11stimulation by the endogenous M₃-like muscarinic receptors^[1].
ML204 hydrochloride blocks LPS-induced TRPC5 channel activity^[3].

ML204 hydrochloride (1 mg/kg; s.c.; twice a day; for 5 days) causes mortality associated with exacerbated hypothermia and decreases peritoneal leukocyte numbers and cytokines in LPS-injected mice^[4].

262.78

Solid

C₁₅H₁₉ClN₂

2070015-10-8

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

H₂O : ≥ 30 mg/mL(114.16 mM)

*"≥" means soluble, but saturation unknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。