AM12 inhibits Lanthanide-evokedTRPC5activity with anIC₅₀of 0.28 μM^[1].

IC50: 0.28 μM (TRPC5)^[1]

AM12 also inhibits TRPC5 activity evoked by the agonist (-)-Englerin A^[1].
AM12 also inhibits TRPC4 channels similarly. AM12 inhibits TRPC5 and TRPC4 channels via a site accessible from the extracellular face of the membrane, acting directly on either the channel or a site closely associated with it^[1].
AM12 also inhibits Ca²⁺entry evoked by Gd³⁺. AM12 inhibits the Gd³⁺-evoked Ca²⁺signal with an IC₅₀of 0.28 μM. AM12 is slightly more potent than the natural product Galangin as an inhibitor of the Gd³⁺-evoked signal^[1].

349.13

C₁₅H₉BrO₅

2387510-84-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.