STAT3-IN-14（Compound 1） 是一种STAT3抑制剂，具有 STAT3 磷酸化抑制活性，可直接与 STAT3的铰链区结合。
| 生物活性 | STAT3-IN-14 (Compound 1) is aSTAT3inhibitor and hasSTAT3phosphorylation inhibitory activity. STAT3-IN-14 (Compound 1) can directly bind to the hinge region ofSTAT3[1]. |
| IC50& Target | IC50: 0.42 μM (MDA-MB-231); 0.50 μM (MCF7); 0.13 μM (A549)[1] |
体外研究
(In Vitro) | STAT3-IN-14 (Compound 1) shows inhibitory activity against phosphor-STAT3.
STAT3-IN-14 (Compound 1) reduces the phosphorylation inhibitory activity against MDA-MB-231 cells (JAK/STAT pathway constitutively active) in does dependent manner, but no inhibitory activities against JAK kinases.
STAT3-IN-14 (Compound 1) has growth inhibitory activity with with IC50values of 0.42 μM, 0.50 μM and 0.13 μM in MDA-MB-231, MCF7 and A549cells, respectively[1].
Western Blot Analysis[1] | Cell Line: | MCF7 cells; MDA-MB-231 cells | | Concentration: | 1 or 10 μM; 0.5, 1, 2, 4 μM | | Incubation Time: | 1 h; 2 h | | Result: | Completely inhibited STAT3 phosphorylation at 10 μM, and partial inhibition at 1 μM.
Reduced the phosphorylation of STAT3 in does dependent manner. |
Cell Proliferation Assay[1] | Cell Line: | MDA-MB-231, MCF7 and A549 cells | | Concentration: | 0-30 μM | | Incubation Time: | 72 h | | Result: | Showed moderate to strong growth inhibitory activity among the three cancer cell lines. |
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| 结构分类 | - Quinones
- Naphthalene Quinones
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| 来源 | - Plants
- Solanaceae
- Nicotiana tabacumL.
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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