您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > STAT3-IN-14
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
STAT3-IN-14
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
STAT3-IN-14图片
CAS NO:123297-90-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
STAT3-IN-14(Compound 1) 是一种STAT3抑制剂,具有 STAT3 磷酸化抑制活性,可直接与 STAT3的铰链区结合。
生物活性

STAT3-IN-14 (Compound 1) is aSTAT3inhibitor and hasSTAT3phosphorylation inhibitory activity. STAT3-IN-14 (Compound 1) can directly bind to the hinge region ofSTAT3[1].

IC50& Target

IC50: 0.42 μM (MDA-MB-231); 0.50 μM (MCF7); 0.13 μM (A549)[1]

体外研究
(In Vitro)

STAT3-IN-14 (Compound 1) shows inhibitory activity against phosphor-STAT3.
STAT3-IN-14 (Compound 1) reduces the phosphorylation inhibitory activity against MDA-MB-231 cells (JAK/STAT pathway constitutively active) in does dependent manner, but no inhibitory activities against JAK kinases.
STAT3-IN-14 (Compound 1) has growth inhibitory activity with with IC50values of 0.42 μM, 0.50 μM and 0.13 μM in MDA-MB-231, MCF7 and A549cells, respectively[1].

Western Blot Analysis[1]

Cell Line:MCF7 cells; MDA-MB-231 cells
Concentration:1 or 10 μM; 0.5, 1, 2, 4 μM
Incubation Time:1 h; 2 h
Result:Completely inhibited STAT3 phosphorylation at 10 μM, and partial inhibition at 1 μM.
Reduced the phosphorylation of STAT3 in does dependent manner.

Cell Proliferation Assay[1]

Cell Line:MDA-MB-231, MCF7 and A549 cells
Concentration:0-30 μM
Incubation Time:72 h
Result:Showed moderate to strong growth inhibitory activity among the three cancer cell lines.
分子量

258.23

Formula

C14H10O5

CAS 号

123297-90-5

结构分类
  • Quinones
  • Naphthalene Quinones
来源
  • Plants
  • Solanaceae
  • Nicotiana tabacumL.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.