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Atracurium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Atracurium图片
CAS NO:64228-79-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
BW-33A free acid
产品介绍
Atracurium (BW-33A free acid) 是一种有效的、竞争性的和非去极化的神经肌肉阻滞剂 (neuromuscular blocking)。Atracurium 还是一种 AChR 受体拮抗剂。Atracurium 可诱导支气管收缩和神经肌肉阻滞。Atracurium 促进星形胶质细胞分化[5]
生物活性

tracurium (BW-33A free acid) is a potent, competitive and non-depolarizingneuromuscular blockingagent.Atracurium also is an AChR receptor antagonist. Atracurium induces bronchoconstriction and neuromuscular blockade. Atracurium promotes astroglial differentiation[1][2][3][4][5].

体外研究
(In Vitro)

Atracurium (10 μM; 72 h) promotes astroglial but not neuronal differentiation in HSR040622 and HSR040821 cells[4].
Atracurium (10 μM; 48 h) reduces tumor engraftment and increases survival of mice xenotransplanted with ex-vivo treated GSCs[4].
Atracurium (2.4 μM; 120 min) induces a complete fade of the tetanic contraction while only slightly affected the twitch in rat extensor digitorum longus muscle cells[5].

Cell Proliferation Assay[4]

Cell Line:glioblastoma stem (GSC) cells
Concentration:3, 10, 20 μM
Incubation Time:72 h
Result:Increased the percentage of GFP-positive cells in a dose-dependent manner from 5.3% in DMSO to 15.4%, 81.1%, and 86.8% in 3 μM, 10 μM, and 20 μM, respectively.
体内研究
(In Vivo)

Atracurium (1, 5, 10, 20, 50 mg/kg; i.v.) induces bronchoconstriction in DBA/2 and SJL mice[2].
Atracurium (4.8 mg/kg; i.v.) induces neuromuscular blockade in rats[3].

Animal Model:5-12 weeks, 15-20 g male mice[2]
Dosage:1, 5, 10, 20, 50 mg/kg
Administration:I.v.
Result:Induced bronchoconstriction and Atracurium-induced airway hyperresponsiveness in DBA/2 mice was eliminated in a dose-dependent manner by pretreatment with atropine or pancuronium.
Animal Model:290 ± 30 g Male Sprague±Dawley rats (60 mg/kg heat-killedCorynebacteriumparvumfor i.v.)[3]
Dosage:4.8 mg/kg
Administration:I.v.
Result:Induced neuromuscular blockade inCorynebacteriumparvum-injected rats.
Clinical Trial
分子量

929.14

Formula

C53H72N2O122+

CAS 号

64228-79-1

中文名称

阿曲库铵

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.