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ODN 21158
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1964506-31-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
ODN 21158 是一种有效的 G 修饰的TLR3TLR9抑制剂。ODN 21158 没有细胞毒性。ODN 21158 以剂量依赖性方式抑制 IFN-α 分泌。
生物活性

ODN 21158 is a potent G-modifiedTLR3andTLR9inhibitor. ODN 21158 shows no cytotoxic. ODN 21158 inhibits IFN-α secretion in a dose dependent manner[1].

体外研究
(In Vitro)

ODN 21158 (0.01, 0.1, 1, 10 μM) shows no cytotoxic in human PBMCs[1].
ODN 21158 (0.01, 0.1, 1, 10 μM; 24 h) inhibits IFN-α secretion in a dose dependent manner when stimulated with CpG-ODN 2216 (3 μM) in Human PBMCs[1].
ODN 21158 (0.01, 0.1, 1, 10 μM; 48 h) stimulated with CpG-ODN 2006 (100 nM) failes to inhibit IL-6 release of PBMCs[1].
ODN 21158 (0.01, 0.1, 1, 10 μM; 48 h) inhibits the release of IL-6 when stimulated with imiquimod (5 μg/ml) in human PBMCs[1].
ODN 21158 (0.1, 1, 10 μM; 24 h) inhibits the release of IL-6 in B-cells when stimulated with imiquimod (5 μg/ml) and CpG-ODN 2006 (100 nM)[1].

Cell Cytotoxicity Assay[1]

Cell Line:human PBMCs
Concentration:0.01, 0.1, 1, 10 μM
Incubation Time:48 h
Result:Did not result in increased levels of extracellular LDH and not reduced the intracellular ATP-levels of CpG-ODN 2006-stimulated PBMCs.
CAS 号

1964506-31-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.