KW-8232 free base, an orally active anti-osteoporotic agent, and can reduces the biosynthesis ofPGE2^[1].

Prostaglandin Receptor^[1]

KW-8232 is an anti-osteoporotic agent. KW-8232 reduces the biosynthesis of PGE₂in mouse osteoblastic cells^[1].
KW-8232 possesses anti-viral activity against SARS-CoV-2 (EC₅₀~1.2 μM )^[2].

KW-8232 (3, 10, 30 mg/kg, p.o.) potently increases the femoral bone mineral density (BMD) of immobilized legs of rats, and affects immobilization-induced abnormal bone turnovrer. KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg, and highly reduces urinary pyridinoline and deoxypyridionline excretion which are markers of bone resorption in neurectomized rats. KW-8232 inhibits bone loss may be attributed to the lower prostaglandins (PGs)-stimulated bone resorption via regulation of PGE2 production^[1].

609.16

Solid

C₃₆H₃₇ClN₄O₃

170365-25-0

Room temperature in continental US; may vary elsewhere.