SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenousAVP^[1].

SKF 100398 is a specific antagonist of the hydrosmotic effect of exogenous and endogenous AVP^[1].
SKF 100398 (8 μg/kg; i.v.) abolishes the antidiuretic effect of AVP^[1].

1136.39

Solid

C₅₃H₇₇N₁₃O₁₁S₂

77453-01-1

{(1-Mercaptocyclohexyl)acetyl}-{Tyr(O-Ethyl)}-Phe-Val-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge: 1-Cys6)

{(1-Mercaptocyclohexyl)acetyl}-{Tyr(O-Ethyl)}-YFVNCPRG-NH2 (Disulfide bridge: 1-Cys6)

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)