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CTAP
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:103429-32-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
CTAP 是一种强效、高选择性的、可透过血脑屏障的阿片受体 (μ opioid receptor) 拮抗剂,IC50为 3.5 nM。CTAP 对δ opioid受体 (IC50=4500 nM) 和生长抑素受体 (somatostatin receptors) 具有超过 1200 倍的选择性。CTAP 可用于 L- 多巴胺 (HY-N0304) 诱导的运动障碍 (LID) 和阿片类药物过量或成瘾的研究。
生物活性

CTAP is a potent, highly selective, and BBB penetrantμopioid receptorantagonist, with anIC50of 3.5 nM. CTAP displays over 1200-fold selectivity overδ opioid(IC50=4500 nM) andsomatostatin receptors. CTAP can be used for the study of L-DOPA-induced dyskinesia (LID) and opiate overdose or addiction[1][2].

IC50& Target

μ Opioid Receptor/MOR

3.5 nM (IC50)

δ Opioid Receptor/DOR

4500 nM (IC50)

体内研究
(In Vivo)

CTAP (0-1 mg/kg, IP, single) blocks morphine’s antinociceptive effect[1].
CTAP (10 mg/kg; IP, single) has no effect on L-DOPA-induced limb, axial, orolingual, or locomotor abnormal involuntary movements[1].
CTAP is stable in the blood and serum of rats (T1/2>500 min), showing that the structure of this peptide offers enzymatic resistance[2].
CTAP is extensively protein-bound to albumin in the perfusion medium (68.2%) and to proteins in rat serum (84.2%)[2].

Animal Model:Male Sprague-Dawley rats[1]
Dosage:0, 0.1, 0.5, 1 mg/kg
Administration:IP, single
Result:Completely blocked morphine’s antinociceptive effect at 0.5 or 1 mg/kg.
分子量

1104.30

Formula

C51H69N13O11S2

CAS 号

103429-32-9

Sequence

{d-Phe}-Cys-Tyr-{d-Trp}-Arg-Thr-{Pen}-Thr-NH2 (Disulfide bridge:Cys2-Pen7)

Sequence Shortening

{d-Phe}-CY-{d-Trp}-RT-{Pen}-T-NH2 (Disulfide bridge:Cys2-Pen7)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.