[Met5]-Enkephalin, amide is an agonist forδ opioid receptorsas well as putativeζ (zeta) opioid receptors.

δ and ζ opioid receptor^[1]

[Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 μM significantly reduces the total number of glial cells in culture^[1]. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC₅₀value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine^[2].

572.68

C₂₇H₃₆N₆O₆S

60117-17-1

Tyr-Gly-Gly-Phe-Met-NH2

YGGFM-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.