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[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic polypeptide TFA
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide 是一种有效的，选择性神经肽 YY5受体激动剂，与 hY5受体结合的IC50值为 0.24 nM。[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide 增加饮食摄入量。
生物活性

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide is a potent and selectiveneuropeptide Y Y5receptor agonist with anIC50of 0.24 nM for binding to the hY5receptor. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide induces a high amount of food intake[1].

IC50& Target[1]

hY5receptor

0.24 nM (IC50)

hY1receptor

530 nM (IC50)

hY2receptor

>500 nM (IC50)

hY4receptor

51 nM (IC50)

体外研究
(In Vitro)

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide hasIC50s of 530 nM, >500 nM, 51 nM for binding to the hY1, hY4, hY2receptors[1].

体内研究
(In Vivo)

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34]-hPancreatic Polypeptide (0.2, 2 nmol/rat) induces a high amount of food intake in a dose-dependent manner in adult male rats weighing 340-400 g[1].

分子量

4321.68

Formula

C185H282F3N57O56S2

Sequence Shortening

GPSQPTYPGDNATPEQMARYYSALRRYINMA{Aib}RQRY-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

 ContentsAssign value
Acidic amino acidAsp (D), Glu (E), and the C-terminal -COOH.-1
Basic amino acidArg (R), Lys (K), His (H), and the N-terminal -NH2+1
Neutral amino acidGly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)0

3.  Recommended solution:

Overall charge of peptideDetails
Negative (<0)1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.