CAS NO: | 158848-32-9 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptideneurokinin 2 (NK2) receptorantagonist. GR 159897 has little or no affinity for NK1and NK3receptors. GR 159897 inhibits binding of [3H]GR100679 tohuman NK2(hNK2)-CHO cells and rat colon membranes withpKis of 9.51 and 10, respectively. Antagonizes bronchoconstriction. Anxiolytic-like and anti-tumor effects[1][2]. | ||||||||||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | GR 159897 (10-30 μM; 72 hours; 4T1, 4THM, 4TLM and 67NR cells) treatment inhibits proliferation of cells in all cell lines dose- dependently, a response more pronounced in 4T1, 4THM and 4TLM cells compared to 67NR cells[2]. Cell Proliferation Assay[2]
Western Blot Analysis[2]
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体内研究 (In Vivo) | GR 159897 (0.12 mg/kg; intravenous injection; guinea-pigs) treatment potently antagonizes bronchoconstriction induced by GR64349, with a long duration of action (3 h)[1].
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分子量 | 414.54 | ||||||||||||||||
Formula | C23H27FN2O2S | ||||||||||||||||
CAS 号 | 158848-32-9 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |