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Irsogladine maleate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Irsogladine maleate图片
CAS NO:84504-69-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
马来酸伊索拉定
Dicloguamine maleate
MN1695
产品介绍
Irsogladine马来酸盐是PDE4抑制剂和毒蕈碱乙酰胆碱受体结合剂。
生物活性

Irsogladine is aPDE4 inhibitorandmuscarinic acetylcholine receptorbinder. Target:PDE4;mACHRIrsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P< 0.02, P< 0.001), in tPA-deficient mice by 42.6 and 46% (P< 0.001, P< 0.001), and in uPA-deficient mice by 27.2 and 46% (P< 0.05, p< 0.001), respectively. Irsogladine inhibits bFGF-induced angiogenesis in wild-type, tPA-knockout, and uPA-knockout mice [1]. Irsogladine up-regulates GJIC between PC cells via regulation of thePKApathway. It also suggests a useful adjuvant of Irsogladine to pancreaticcancertherapy [2]. irsogladine produces the increase of intracellular cAMP content via non-selective inhibition of PDE isozymes, which may be a key mechanism involved in its gastroprotective actions [3].

IC50& Target

PDE4

 

Clinical Trial
分子量

372.16

Formula

C13H11Cl2N5O4

CAS 号

84504-69-8

中文名称

马来酸伊索拉定

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.