Dihydrexidine

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Dihydrexidine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

123039-93-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

DAR-0100

产品介绍

Dihydrexidine (DAR-0100) 是一种高效、选择性和全效的 D1 样多巴胺受体(D1/D5)激动剂，对 D1 受体作用的IC₅₀值为 10 nM。Dihydrexidine 具有高效的抗帕金森活性。Dihydrexidine 可以刺激 YAP 磷酸化。

生物活性

Dihydrexidine (DAR-0100) is a high potent, selective and full efficacyD1-likedopamine receptor(D1/D5)agonist with anIC₅₀of 10 nM for D1 receptor. Dihydrexidine exhibits potent antiparkinsonian activity^[1]^[2]^[3]^[4]. Dihydrexidine can stimulateYAPphosphorylation^[5].

IC₅₀& Target

IC50: 10 nM (D1 dopamine receptor), D5 dopamine receptor, 660 nM (D1 dopamine receptor)^[1]

体外研究
(In Vitro)

Dihydrexidine (DAR-0100) strongly increased YAP phosphorylation in U2OS cells^[5].

体内研究
(In Vivo)

Dihydrexidine has poor oral bioavailability and a relatively short half-life of 1 to 2 h^[3].
Dihydrexidine (3 mg/kg; i.p.) produces prominent dopamine D1 receptor agonist effects in vivo^[4].

Animal Model:	Adult male Sprague–Dawley rats (275-300 g)^[4]
Dosage:	Adult male Sprague–Dawley rats (275-300 g)^[4]
Administration:	Intraperitoneal injection
Result:	Produces prominent dopamine D1 receptor agonist effects in vivo

Clinical Trial

分子量

267.32

Formula

C₁₇H₁₇NO₂

CAS 号

123039-93-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.