(+)-Dihydrexidine hydrochloride ((+)-DAR-0100 hydrochloride) is adopamine D1 receptoragonist with anEC₅₀of 72± 21 nM.

EC50: 72±21 nM (Dopamine D1 receptor)^[1]

(+)-Dihydrexidine hydrochloride (DHX) is a high-potency, bioavailable D1 dopamine receptor agonist. (+)-Dihydrexidine is screened for activity against 40 other binding sites, and is inactive (IC₅₀greater than 10 microM) against all except D2 dopamine receptors (IC₅₀=130 nM) and alpha 2 adrenoreceptors (IC₅₀=230 nM). Dihydrexidine competes stereoselectively and potently for D1 binding sites in rat striatal membranes labeled with [³H]SCH23390 with an IC₅₀of about 10 nM compared to about 30 nM for the prototypical D1 agonist SKF38393^[2].

To examine the functional state of striatal neurons in response to D1 receptor activation,AC5^+/+andAC5^-/-mice are injected with the D1 agonist (+)-Dihydrexidine (30 mg/kg, i.p.) and obtained the dorso-lateral striatum and NAc, separately, 45 min later for RT-PCR analysis. These experiments reveal that (+)-Dihydrexidine -triggered induction of the immediate early genes,c-fos,egr-1, andjunB, in the NAc is markedly enhanced inAC5^-/-mice compared with that inAC5^+/+mice, while the induction in the dorso-lateral striatum is suppressed inAC5^-/-mice^[3].

303.78

C₁₇H₁₈ClNO₂

158704-02-0

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.