Ropinirole (SKF 101468) is an orally active, potent D₃/D₂receptor agonist with aK_iof 29 nM forD₂receptor. Ropinirole haspEC₅₀s of 7.4, 8.4 and 6.8 for hD₂, hD₃and hD₄receptors, respectively. Ropinirole has no affinity for the D₁receptors. Ropinirole has the potential for Parkinson's disease^[1][2].

Ropinirole has affinity for D₃receptors of 10-20 fold higher than the D₂and D₄receptors. Ropinirole is weakly active at alpha 2-adrenoceptors and 5-HT₂receptors but inactive at 5-HT₁, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors^[1][2].

Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory^[2].

260.37

C₁₆H₂₄N₂O

91374-21-9

罗匹尼罗

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.