SKF-82958

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SKF-82958

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

80751-65-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

(±)-SKF-82958
Chloro-APB

产品介绍

SKF-82958 ((±)-SKF 82958) 是多巴胺D1受体激动剂 (K_0.5=4 nM)，对 D1 受体有选择性(K_0.5=73 nM)。SKF-82958 诱导大鼠纹状体膜多巴胺 D1 受体依赖性腺苷酸环化酶活性(EC₅₀=491 nM)。

生物活性

SKF-82958 ((±)-SKF 82958) is adopamine D1 receptorfull agonist (K_0.5=4 nM), displays selective for D1 over D2 receptors (K_0.5=73 nM). SKF-82958 induces dopamine D1 receptor-dependentadenylate cyclaseactivity in rat striatal membranes (EC₅₀=491 nM)^[1].

体内研究
(In Vivo)

SKF-82958 ((±)-SKF 82958) (0.003-0.1 mg/kg; i.p.) results in dose-dependent increases in responding on the SKF-82958 appropriate lever, with full substitution following administration of the SKF-82958 training dose 0.03 mg/kg. Increasing the dose of SKF-82958 also results in a significant reduction in response rate^[2].
SKF-82958 (0.5-2.0 mg/kg; i.p) significantly suppresses pilocarpine-induced jaw movements^[3].

Animal Model:	Male Sprague-Dawley rats^[3]
Dosage:	0.5-2.0 mg/kg
Administration:	I.p
Result:	Significantly reduced the number of tremulous jaw movements induced by 4.0 mg/kg pilocarpine.

分子量

329.82

Formula

C₁₉H₂₀ClNO₂

CAS 号

80751-65-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.