CAS NO: | 155271-17-3 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | KF21213 is a highly selective ligand for mapping CNS adenosineA2Areceptors. KF21213 shows a high affinity for the adenosineA2Areceptors (Ki=3.0 nM). |
IC50& Target | Ki: 3.0 nM (A2Areceptor)[1] |
体外研究 (In Vitro) | [11C]KF21213 as a PET ligand for mapping adenosine A2Areceptors in the central nervous system (CNS). KF21213 shows a high affinity for the adenosine A2Areceptors in vitro (Ki=3.0 nM) and a very low affinity for the A1receptors (Ki>10,000 nM)[1]. |
体内研究 (In Vivo) | The uptake of [11C]KF21213 by the striatum gradually increases for the first 15 min and then decreases. The uptake by the cortex and cerebellum is rapidly decreased after injection. Their levels are compatible with that in the blood. Consequently, the uptake ratios of striatum to cortex and striatum to cerebellum increases up to 8.6±1.6 and 10.5±2.1 (N=4), respectively, by 60 min. The striatal activity level of [11C]KF21213 is retained for the initial 5 min and then gradually decreased with time, whereas that of [11C]KF18446 rapidly decreases.The cerebellar activity of the two ligands rapidly decreases.The striatum-to-cerebellum uptake ratio for [11C]KF21213 gradually increases to 2.4 6 0.5 (N 5 3) by 50-60 min, whereas that for [11C]KF18446 increases for the first 10 min and remains constant (1.4±0.3, N=3, at 25-35 min)[1]. |
分子量 | 354.40 |
Formula | C19H22N4O3 |
CAS 号 | 155271-17-3 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |