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Quinine sulfate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Quinine sulfate图片
CAS NO:549-56-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
奎宁硫酸盐
产品介绍
Quinidine sulfate 是一种抗心律失常剂。Quinidine sulfate 是一种有效的、具有口服活性的、选择性的细胞色素 P450db (cytochrome P450db) 抑制剂,也是 K+通道 (K+channel) 的有效阻断剂,其IC50值为 19.9 μM。Quinidine sulfate 也可用作疟疾的研究。
生物活性

Quinidine is an antiarrhythmic agent. Quinidine is a potent, orally active, selectivecytochrome P450dbinhibitor. Quinidine is also aK+channelblocker with anIC50of 19.9 μM. Quinidine can be used for malaria research[1][2][3].

体外研究
(In Vitro)

Quinidine sulfate is an anti-arrythmic drug which affects ionic currents in heart muscle and which has also been shown to be a potent blocker of several classes of K+channel in a variety of cell types[1].
Bath application of quinidine sulfate causes a dose-dependent reduction of the peak amplitude of Ik. The Kdfor blockade of Ikat 0 mV is estimated to be 41 μM[1].
Quinidine sulfate elicits a dose-dependent increase of the rate of the decay of Ikand this effect is enhanced by membrane depolarization. Quinidine also causes a 5 mV hyperpolarizing shift of the steady-state inactivation curve and increases the half-time for recovery from inactivation. Quinidine does not affect the onset of inactivation measured at -30 mV[1].

体内研究
(In Vivo)

Quinidine sulfate is rapidly absorbed, with peak plasma concentrations 60-90 min after an oral dose. Other salts (gluconate, polygalacturonate) are more slowly absorbed, with lower peak concentrations[2].
Quinidine sulfate is approximately 70-90 % bound to plasma proteins. It undergoes hepatic oxidative metabolism to form an N-oxide, a 3-hydroxy form, an O-demethyl form and 2'-quinidinone[2].
Quinidine sulfate inhibits metabolism of amphetamine in rats. Quinidine pretreatment results in a significant decrease in the excretion of p-hydroxyamphetamine at 24 and 48 h to 7.2 and 24.1% of the vehicle-control levels, respectively, accompanied by a significant increase in amphetamine excretion between 24 and 48 h to 542% of the control[3].

分子量

422.50

Formula

C20H26N2O6S

CAS 号

549-56-4

中文名称

奎宁硫酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.