Quinine sulfate(2:1)

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

804-63-7

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

硫酸奎宁

产品介绍

Quinine sulfate (2:1) (Qualaquin) 是一种从金鸡纳树皮中提取的生物碱，具有口服活性，可用作抗疟疾研究。Quinine sulfate (2:1) 是一种钾离子通道 (potassium channel) 抑制剂，可抑制电压脉冲引起的 MT mSlo3 (K_Ca5.1) 通道 +100 mV 电流, 其IC₅₀值为 169 μM。

生物活性

Quinine sulfate (2:1) (Qualaquin) is an orally active alkaloid extracted from cinchona bark and can be used in anti-malarial studies. Quinine sulfate (2:1) is apotassium channelinhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with anIC₅₀of 169 μM^[1]^[2].

体外研究
(In Vitro)

Quinine sulfate (150 μM, 30 min) inhibits the proliferation and cytostatic effects of DENV (Dengue virus) in human hepatocarcinoma HepG2 cell line^[1].
Quinine sulfate (37.5-150 μM, 24 hours) significantly reduces viral DENV RNA and protein levels in a dose-dependent manner in human hepatocarcinoma HepG2 cell line^[1].

Cell Proliferation Assay^[1]

Cell Line:	Human hepatocarcinoma cell line(HepG2)
Concentration:	150 μM
Incubation Time:	30 min
Result:	Inhibited DENV virus replication with 19% yield compared to untreated. Reduced DENV-positive cells from 23.28% to 12.05% in a dose-dependent manner.

体内研究
(In Vivo)

Quinine sulfate (oral gavage, 12 or 15 mg/kg, every week, 16 weeks) has some tumor suppressing effect on skin cancer in Swiss albino mice^[2].
Quinine sulfate (oral gavage, 10 mg/kg, everyday, 8 weeks) causes a decrease in the antioxidant defense system of rat testicular tissue such as SOD, CAT and GSH enzyme activity in male adult albino rats^[3].

Animal Model:	Swiss albino mice 7-8-weeks (weighing 24 g)^[2]
Dosage:	12 mg/kg, 15 mg/kg
Administration:	Oral gavage; every week; 16 weeks
Result:	Resulted in a significant reduction in tumor size and weight at 12 mg/kg and little effect at higher dose of 15 mg/kg.

Clinical Trial

分子量

746.91

Formula

C₄₀H₅₀N₄O₈S

CAS 号

804-63-7

中文名称

硫酸奎宁

结构分类

Alkaloids
Quinoline Alkaloids

来源

Plants
Rubiaceae
Cinchona succirubraPav. ex Klotzsch

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.