您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Kushenol K
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Kushenol K
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Kushenol K图片
CAS NO:101236-49-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品名称
苦参醇K
产品介绍
Kushenol K,一种从Sophora flavescens中提取的黄酮类抗氧化剂。Kushenol K 是CYP3A4的抑制剂,Ki值为 1.35 μM。Kushenol K 对HSV-2具有较弱的抗病毒活性 (EC50为 147 μM)。Kushenol K 还抑制SGLT1SGLT2的活性。
生物活性

Kushenol K, a flavonoid antioxidant isolated from the roots ofSophora flavescens. Kushenol K is acytochrome P-450 3A4 (CYP3A4)inhibitor with aKivalue of 1.35 μM[1]. Kushenol K shows weak antiviral activity againstHSV-2(EC50of 147 μM)[2]. Kushenol K also inhibits the activity ofSGLT1andSGLT2[3].

IC50& Target[1][2][3]

CYP3A4

1.35 μM (Ki)

CYP3

 

SGLT1

 

SGLT2

 

HSV-2

147 μM (EC50)

体外研究
(In Vitro)

When Midazolam is used as the substrate of CYP3A4, Kushenol K exhibits the strong inhibition with an IC50values of 1.62 μM[1].
At a concentration of 50 μM, the inhibition rate of Kushenol K on SGLT1 is 29.7%, and the inhibition rate on SGLT2 is 43.7%[3].

分子量

472.53

Formula

C26H32O8

CAS 号

101236-49-1

中文名称

苦参醇K;苦参醇 K

结构分类
  • Flavonoids
  • Flavanonols
  • Phenols
  • Polyphenols
来源
  • Plants
  • Leguminosae
  • Sophora flavescens
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.