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TA-1887
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TA-1887图片
CAS NO:1003005-29-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
JNJ-39933673
产品介绍
TA-1887 (JNJ-39933673) 是一种高效的、选择性的、具有口服活性的SGLT2抑制剂 (IC50: 1.4 nM),具有降血糖作用。TA-1887 可用于糖尿病研究。
生物活性

TA-1887 (JNJ-39933673) is a highly potent, selective and orally activeSGLT2inhibitor (IC50: 1.4 nM) with antihyperglycemic effects. TA-1887 can be used in the research of diabetes[1][2].

IC50& Target[1]

SGLT2

1.4 nM (IC50)

SGLT1

230 nM (IC50)

体内研究
(In Vivo)

TA-1887 (30 mg/kg, oral administration, rats) induces glucose excretion over a 24 h period of 2502 mg per 200 g body weight[1].
TA-1887 (3 mg/kg, oral administration) reduces blood glucose levels without influencing food intake in hyperglycemic high-fat diet-fed KK (HF-KK) mice[1].
TA-1887 (30 mg/kg/day, oral gavage for 2 weeks) significantly reduces GFR (glomerular filtration rate) in BSA-overloaded diabetic mice[2].
TA-1887 (0.01% w/w in chow, HF diets fed mice) antagonizes diabetic cachexia and decreases mortality in diabetic mice[3].

Animal Model:Sprague-Dawley rats[1]
Dosage:30 mg/kg
Administration:Oral administration
Result:Induced extensive UGE (urinary glucose excretion) through continuous suppression of renal glucose reuptake.
Animal Model:BSA-overloaded diabetic mice[2]
Dosage:30 mg/kg
Administration:Oral gavage for 2 weeks
Result:Suppressed the induction of TGF‐β2 level in vehicle‐ reated BSA‐overloaded diabetic mice.
Suppressed COL3 gene levels.
Animal Model:Male Sprague-Dawley rats (pharmacokinetic assay)[1]
Dosage:3 mg/kg (i.v.), 10 mg/kg (p.o.)
Administration:Oral administration (p.o.), intravenous injection (i.v.)
Result:Pharmacokinetic (PK) parameters of TA-1887.
Parametersdose (mg/kg)Cmax(ng/mL)t1/2(h)F (%)
TA-18873(i.v.)3.9
TA-1887310 (p.o.)27233.978
分子量

427.47

Formula

C24H26FNO5

CAS 号

1003005-29-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.