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Bursehernin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bursehernin图片
CAS NO:40456-51-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
Methylpluviatolide
产品介绍
Bursehernin (Methylpluviatolide) 是一种抗肿瘤剂。Bursehernin 诱导细胞凋亡 (Apoptosis) 和细胞周期停滞在 G2/M 期。Bursehernin 具有抗增殖活性。
生物活性

Bursehernin (Methylpluviatolide) is an antitumor agent. Bursehernin inducesApoptosisand cell cycle arrest at G2/M phase. Bursehernin shows anti-proliferative activity[1][2].

体外研究
(In Vitro)

Bursehernin (4.3 μM for MCF-7 cells, 3.7 μM for KKU-M213 cells; 4, 48, 72 h) 以时间依赖的方式诱导细胞凋亡和细胞周期停滞在G2/M期[1]

Cell Proliferation Assay[1]

Cell Line:MCF-7, MDA-MB-468, MDA-MB-231, HT-29, KKU-M213, KKU-K100, KKU-M055, L-929, MMNK-1 cells
Concentration:0-100 μM
Incubation Time:72 h
Result:Showed anti-proliferative activity with IC50s of 11.96, 8.24, 14.26, 47.53, 3.70, 12.38, 17.38, 26.36, 7.45 μM for MCF-7, MDA-MB-468, MDA-MB-231, HT-29, KKU-M213, KKU-K100, KKU-M055, L-929, MMNK-1 cells, respectively.

Cell Cycle Analysis[1]

Cell Line:MCF-7, KKU-M213 cells
Concentration:4.3 μM for MCF-7 cells, 3.7 μM for KKU-M213 cells
Incubation Time:24, 48, 72 h
Result:Induced cell cycle arrest at G2/M phase.

Western Blot Analysis[1]

Cell Line:MCF-7, KKU-M213 cells
Concentration:4.3 μM for MCF-7 cells, 3.7 μM for KKU-M213 cells
Incubation Time:24, 48, 72 h
Result:Decreased the expression of topoisomerase II, STAT 3, cyclin D1, and p21.

Apoptosis Analysis[1]

Cell Line:MCF-7 cells
Concentration:0, 2.15, 4.30, 8.60 μM
Incubation Time:24, 48, 72, 96 h
Result:Induced apoptosis in a time- and dose-dependent manner.
分子量

370.40

Formula

C21H22O6

CAS 号

40456-51-7

结构分类
  • Phenylpropanoids
  • Lignans
来源
  • Plants
  • other families
  • Hernandia sonoraLinn.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.