Coleon-U-quinone

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Coleon-U-quinone

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

65714-83-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Coleon-U-quinone 是一种有效的P-gp抑制剂。Coleon-U-quinone 能抑制癌细胞活力，能提高多药耐药肿瘤细胞对 Doxorubicin (HY-15142A) 的敏感性。

生物活性

Coleon-U-quinone is a potentP-gpinhibitor. Coleon-U-quinone can inhibitcancercells viability and sensitize multidrug resistancecancercells toDoxorubicin(HY-15142A)^[1].

IC₅₀& Target

P-glycoprotein^[1]

体外研究
(In Vitro)

Coleon-U-quinone (0-50 μM; 72 h) has inhibitory activity against NCI-H460, NCI-H460/R and MRC-5^[1].
Coleon-U-quinone (1-5 μM; 72 h) sensitize NCI-H460/R cells toDoxorubicin(HY-15142A)^[1].

Cell Viability Assay^[1]

Cell Line:	NCI-H460, NCI-H460/R and MRC-5
Concentration:	0-50 μM
Incubation Time:	72 h
Result:	Exhibited inhibitory activity against NCI-H460, NCI-H460/R and MRC-5 with IC₅₀s of 22.96 ± 0.56 μM, 20.37 ± 0.43 μM and 44.13 ± 1.19 μM.

Cell Proliferation Assay^[1]

Cell Line:	NCI-H460/R
Concentration:	1, 2 and 5 μM
Incubation Time:	72 h
Result:	Sensitized NCI-H460/R cells toDoxorubicin(HY-15142A) with IC₅₀s of 0.565 μM, 0.482 μM and 0.217 μM at 1 μM, 2 μM and 5 μM, respectively.

分子量

344.40

Formula

C₂₀H₂₄O₅

CAS 号

65714-83-2

结构分类

Ketones, Aldehydes, Acids

来源

Plants
Labiatae
Plectranthus mutabilisCodd

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.