Peramivir (RWJ-270201;BCX-1812) 是一种高效、选择性和口服活性的流感病毒神经氨酸酶 (NA) 抑制剂，对九种 NA 亚型的 IC50 值范围为 0.9 至 4.3 nM。
| Cas No. | 330600-85-6 |
| 别名 | 帕拉米韦; RWJ-270201; BCX-1812 |
| 化学名 | (1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid |
| Canonical SMILES | CCC(CC)C(C1C(CC(C1O)C(=O)O)N=C(N)N)NC(=O)C |
| 分子式 | C15H28N4O4 |
| 分子量 | 328.41 |
| 溶解度 | ≥ 7.6 mg/mL in EtOH, ≥ 5.66 mg/mL in Water with ultrasonic and warming |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Peramivir is an experimental antiviral drug developed by BioCryst Pharmaceuticals for the treatment of influenza. It has been authorized for the emergency use of treatment of certain hospitalized patients with known or suspected 2009 H1N1 influenza. Peramivir is a neuraminidase inhibitor, acting as a transition-state analogue inhibitor of influenza neuraminidase and thereby preventing new viruses from emerging from infected cells. From Wikipedia |
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