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Bimosiamose Disodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Bimosiamose Disodium图片
CAS NO:187269-60-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
TBC-1269Z
产品介绍
Bimosiamose disodium (TBC-1269Z) 是一种非寡糖泛-selectin抑制剂,对E-selectinP-selectinL-selectinIC50分别为 88 μM,20 μM 和 86μM。Bimosiamose disodium 具有抗炎作用。
生物活性

Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectininhibitor withIC50s of 88 μM, 20 μM, and 86 μM forE-selectin,P-selectin, andL-selectin, respectively. Bimosiamose disodium has anti-inflammatory effects[1].

IC50& Target

IC50: 88 μM (E-selectin), 20 μM (P-selectin), and 86 μM (L-selectin)[1]

体外研究
(In Vitro)

Bimosiamose (TBC-1269) operates by inhibiting neutrophil recruitment to the site of inflammation through blocking the initial rolling phase of recruitment. Bimosiamose (TBC-1269) inhibits cell recruitment and does not possess any cytotoxic effect on neutrophils[1].

体内研究
(In Vivo)

Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion, and also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved[1].

Animal Model:Sprague-Dawley rats (200-225g) with ischemia and reperfusion (I/R)[1]
Dosage:25 mg/kg
Administration:Intravenous injection
Result:Showed a significant increase in survival compared with controls.
Clinical Trial
分子量

906.88

Formula

C46H52Na2O16

CAS 号

187269-60-9

中文名称

比莫西糖二钠盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.