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Neuropeptide W-23(human)(TFA)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
NPW-23 TFA
产品介绍
Neuropeptide W-23 (human) (NPW-23) TFA 是 Neuropeptide W 的主要活性形式，为NPBW1 (GPR7)和NPBW2 (GPR8)的内源性激动剂。
生物活性

Neuropeptide W-23 (human) (NPW-23) TFA, the active form of Neuropeptide W, is an endogenous agonist ofNPBW1 (GPR7)andNPBW2 (GPR8)[1].

IC50& Target

NPBW1, NPBW2[1]

体外研究
(In Vitro)

Neuropeptide W-23 (human) (NPW-23) increases the ICa,Lin transfected human embryonic kidney 293 cells and VSMCs via GPR7[1].
Neuropeptide W-23 (human) increases the expression of pan phospho-PKC, intracellular diacylglycerol level, and the second messenger catalyzed by PLC[1].

体内研究
(In Vivo)

Neuropeptide W-23 (human) (NPW-23) (0.3-3.0 nM; intracerebroventricular injection; 2 μL) increases total behavioral activity, including locomotion and grooming in conscious rats[2].
Neuropeptide W-23 (human) (NPW-23) (2-8 nM; i.c.v.; 10 μL) shows anorexigenic effect in rats[3].

Animal Model:Male Harlan Sprague-Dawley rats, 250–300 g[2]
Dosage:0.3, 1.0 and 3.0 nM
Administration:Intracerebroventricular injection, 2 μL
Result:Caused significant increases in mean arterial pressure. Demonstrated a significant increase in total activity, ambulatory activity, and duration of stereotypy.
Animal Model:Male Wistar rats weighing 250–300 g[3]
Dosage:2, 4, 6 and 8 nM
Administration:Intra-cerebroventricular injection, 10 μL
Result:Decreased dark feeding and fasting-induced feeding, decreased feeding intake and weight gain.
分子量

2697.04

Formula

C122H185F3

Sequence

Trp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ala-Gly-Leu-Met-Gly-Leu

Sequence Shortening

WYKHVASPRYHTVGRAAGLMGL

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.