| CAS NO: | 1314486-37-7 |
| 包装 | 价格(元) |
| 1mg | 电议 |
| 5mg | 电议 |
| Cas No. | 1314486-37-7 |
| 别名 | JBIR 100 |
| 化学名 | 2E-butenedioic acid-1-[(2R,4R,5S,6R)-tetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-6-(1-methylethyl)-2H |
| Canonical SMILES | C[C@H]([C@]1(O)O[C@H](C(C)C)[C@@H](C)[C@H](OC(/C=C/C(O)=O)=O)C1)[C@H](O)[C@@H]([C@](OC(/C(C)=C/C(C)=C/[C@@H](C)[C@@H](O)[C@@H](C)C2)=O)([H])[C@H](/C=C/C=C2\C)OC)C |
| 分子式 | C39H60O11 |
| 分子量 | 704.9 |
| 溶解度 | DMF: soluble,DMSO: soluble,Ethanol: soluble |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | TS 155-2, is a macrocyclic lactone related to hygrolidin, is produced by a different Streptomyces species found in oil. It blocks thrombin-evoked calcium (Ca2+) entry into cells. TS155-2 exerts hypotensive, anti-platelet, anti-ischaemic and anti-inflammatory activity showed on the original patent, however, no literature investigation of TS155-2 is available. A rapid increase in cytosolic Ca2+ is related to the signal transduction events following the induction of thrombin in a wide range of cell types which include fibroblasts, platelets, megakaryocytes, endothelium and smooth muscle. Thrombin-stimulated Ca2+ mobilization has been shown to be involved in both Ca2+ release from internal storage sites and Ca2+influx and has been extensively studied in human platelets. Thrombin triggers phospholipase C resulting in the rapid generation of inositol 1,4,5-trisphosphate (IP3), which elicits the release of Ca2+ from IP3-sensitive stores. However, the thrombin-induced Ca2+ influx is still an area of contention [1]. In vitro: Up to now, in vitro study of TS 155-2 is still in the development stage. In vivo: Up to now, in vivo study of TS 155-2 is still in the development stage. Reference: |
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