MMP-2/MMP-9 Inhibitor I

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

193807-58-8

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议

产品介绍

MMP-2/MMP-9 Inhibitor I 是一种高选择性、口服活性和有效的 IV 型胶原酶（MMP-9 和 MMP-2）抑制剂，IC50 分别为 0.24 和 0.31 μM 分别用于 MMP-9 和 MMP-2 . MMP-2/MMP-9 Inhibitor I 在肿瘤生长和转移的动物模型中具有口服活性。 MMP-2/MMP-9 Inhibitor I可用于癌症研究。

Cas No.	193807-58-8
别名	胶原酶,Metalloproteinase-2/Metalloproteinase-9 Inhibitor I
化学名	N-([1,1'-biphenyl]-4-ylsulfonyl)-D-phenylalanine
Canonical SMILES	O=S(C(C=C1)=CC=C1C2=CC=CC=C2)(N[C@@H](C(O)=O)CC3=CC=CC=C3)=O
分子式	C₂₁H₁₉NO₄S
分子量	381.4
溶解度	≤25mM in DMSO
储存条件	Store at 4℃
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	IC50: 310 and 240 nM for MMP-2 and MMP-9, respectively MMP-2/MMP-9 Inhibitor I is a potent inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9. Matrix metalloproteinase (MMP), a typical metalloproteinase, requires zinc ion at its active sites. As many as 18 kinds of MMP have been identified and cloned and are collectively called the MMP family. In vitro: MMP-2/MMP-9 inhibitor I was identified as a potent inhibitor of matrix metalloproteinase-2 (MMP-2) and MMP-9 with IC50 values of 310 and 240 nM, respectively. MMP-2/MMP-9 inhibitor I acted by binding zinc at the active site of these MMPs. MMP-2/MMP-9 inhibitor I was found to be able to block MMP-2/MMP-9-dependent invasion in cell culture model [1]. In vivo: Both hydroxamic acid and carboxylic acid analogs of MMP-2/MMP-9 inhibitor I were evaluated for their inhibitory activities in animal cancer models. Results showed that lung colonization of Lewis lung carcinoma cells was suppressed by these inhibitors significantly. In addition, antitumor activity was also observed in the human lung cancer model. Ma44 cells growed as a solid tumor on the peritoneum after being implanted ip, and mice bearing Ma44 eventually died within 3 to 4 weeks. Daily oral administration of compound 5l led to prolonged survival of Ma44-bearing mice [1]. Clinical trial: So far, no clinical study has been conducted. Reference: [1] Tamura, Y. ,Watamane, F.,Nakatani, T., et al. Highly selective and orally active inhibitors of type IV collagenase (MMP-9 and MMP-2): N-sulfonylamino acid derivatives. J. Med. Chem. 41(4), 640-649 (1998).