CAS NO: | 440122-66-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | WAY-200070 is a selectiveestrogen receptorβ (ERRβ) agonist with anIC50of 2.3 nM. | ||||||||||||||||
IC50& Target | IC50: 2.3 nM (ERRβ), 155 nM (ERRα)[1] | ||||||||||||||||
体内研究 (In Vivo) | Administration of WAY-200070 (30 mg/kg s.c.) causes nuclear translocation of ERRβ receptors in WT mice. Administration of WAY-200070 (30 mg/kg s.c.) produces a delayed 50% increase in dopamine in the striatum of wild type mice. WAY-200070 (30 mg/kg s.c.) reduces immobility time in the mouse tail suspension test indicating an antidepressant-like effect[1]. In gonadally intact male and female mice WAY-200070 increases agonistic behaviors such as pushing down and aggressive grooming, while leaving attacks unaffected[2]. Ovariectomized (ovx) mice treated with PPT fail to learn the socially acquired preference, while WAY-200070-treated ovx mice shows a two-fold prolonged preference for the food eaten by their demonstrator[3]. WAY-200070, shows significantly decreased anxiety-like behaviors in both the open-field and elevated plus maze and significantly less depressive-like behaviors in the forced swim test[4]. | ||||||||||||||||
分子量 | 306.11 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C13H8BrNO3 | ||||||||||||||||
CAS 号 | 440122-66-7 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : ≥ 31 mg/mL(101.27 mM) *"≥" means soluble, but saturation unknown. 配制储备液
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以下溶剂前显示的百
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