ZINC05007751 is a potent NIMA-related kinaseNEK6inhibitor with anIC₅₀of 3.4 μM. ZINC05007751 shows antiproliferative activity against a panel of humancancercell lines, and displays a synergistic effect with Cisplatin and Paclitaxel in a BRCA2 mutated ovariancancercell line. ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity was observed against NEK2,NEK7, and NEK9^[1].

ZINC05007751 (6 μM-190 μM; 24 hours) inhibits the growth of MDA-MB-231, PEO1, NCI-H1299 and HCT-15 with IC50 below 100 μM^[1].
ZINC05007751 induces perturbation of PEO1 cell cycle^[1].
ZINC05007751 (ovarian cancer cells PEO1) shows synergism with Cisplatin, resulting in a significant reduction of Cisplatin IC50 from 7.9 to 0.1 μM, with combination ZINC05007751 (44 μM) + Cisplatin (10 μM) exhibiting the greatest synergistic effect^[1].

304.30

Solid

C₁₈H₁₂N₂O₃

591239-68-8

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

DMSO : 8.33 mg/mL(27.37 mM;ultrasonic and warming and heat to 60℃)

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。