CAS NO: | 152044-53-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Epothilone A is a competitive inhibitor of the binding of [3H] paclitaxel totubulinpolymers, with aKiof 0.6-1.4 μM. | ||||||||||||||||
体外研究 (In Vitro) | Epothilone A is a competitive inhibitor of the binding of [3H] paclitaxel to tubulin polymers. The apparent Kivalue for Epothilone A is 1.4 μM by Hanes analysis and 0.6 μM by Dixon analysis[1]. Epothilone A, is noted to be highly cytotoxic (IC50=0.05 μM) in vitro when applied to the human T-24 bladder carcinoma cell line. The binding affinity of Epothilone A to tubulin is of the same order of magnitude as the binding affinity of paclitaxel to tubulin based on competition assays. The IC50for displacement of 100 nM of (3H) paclitaxel from the tubulin binding site is 3.6 μM for paclitaxel, 2.3 μM for Epothilone A, and 3.3 μM for patupilone[2]. | ||||||||||||||||
分子量 | 493.66 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C26H39NO6S | ||||||||||||||||
CAS 号 | 152044-53-6 | ||||||||||||||||
结构分类 |
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来源 | Sorangium cellulosum | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 125 mg/mL(253.21 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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