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P-gp inhibitor 5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
P-gp inhibitor 5图片
CAS NO:2451298-06-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
P-gp inhibitor 5 是一种有效的P 糖蛋白 (P-gp)抑制剂。P-gp inhibitor 5 对某些癌细胞有抗增殖活性。P-gp inhibitor 5 可通过恢复细胞对长春新碱 (Vincristine; HY-N0488A) 和紫杉醇 (Paclitaxel; HY-B0015) 的敏感性,有效逆转 ABCB1/Flp-InTM-293 和 KBvin 的多药耐药 (MDR) 表型。
生物活性

P-gp inhibitor 5 is a potentP-glycoprotein(P-gp)inhibitor. P-gp inhibitor 5 has antiproliferative activity against certaincancercell lines. P-gp inhibitor 5 is effective in reversing the multidrug resistance (MDR) phenotype in ABCB1/Flp-InTM-293 and KBvin cells by restoring their sensitivity to Vincristine (HY-N0488A) and Paclitaxel (HY-B0015)[1].

IC50& Target

P-gp[1]

体外研究
(In Vitro)

P-gp inhibitor 5 (compound 10) has cytotoxic against ABCB1/Flp-InTM-293 and KBvin cells with IC50s of 29.7 and 12.6 μM, respectively[1].
P-gp inhibitor 5 (2.5 and 5 μM) lows the IC50s of KBvin cells for Vincristine to 7.59~36.82 nM, for Paclitaxel to 21.0~79.5 nM, for Doxorubicin to 85.7~111 nM; lows the IC50s of HeLaS3 cells for Vincristine to 2.24~3.91 nM, for Paclitaxel to 8.81~9.58 nM, for Doxorubicin to 102~1260 nM[1].

分子量

517.98

Formula

C28H20ClNO5S

CAS 号

2451298-06-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.