P-gp inhibitor 5 is a potentP-glycoprotein(P-gp)inhibitor. P-gp inhibitor 5 has antiproliferative activity against certaincancercell lines. P-gp inhibitor 5 is effective in reversing the multidrug resistance (MDR) phenotype in ABCB1/Flp-In^TM-293 and KBvin cells by restoring their sensitivity to Vincristine (HY-N0488A) and Paclitaxel (HY-B0015)^[1].

P-gp^[1]

P-gp inhibitor 5 (compound 10) has cytotoxic against ABCB1/Flp-In^TM-293 and KBvin cells with IC₅₀s of 29.7 and 12.6 μM, respectively^[1].
P-gp inhibitor 5 (2.5 and 5 μM) lows the IC₅₀s of KBvin cells for Vincristine to 7.59~36.82 nM, for Paclitaxel to 21.0~79.5 nM, for Doxorubicin to 85.7~111 nM; lows the IC₅₀s of HeLaS3 cells for Vincristine to 2.24~3.91 nM, for Paclitaxel to 8.81~9.58 nM, for Doxorubicin to 102~1260 nM^[1].

517.98

C₂₈H₂₀ClNO₅S

2451298-06-7

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