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Toceranib-d8
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Toceranib-d8图片
CAS NO:1795134-78-9
包装与价格:
包装价格(元)
1mg电议
10mg电议

产品名称
托西尼布 d8
产品介绍
Toceranib-d8 (SU11654-d8) 是 Toceranib 的氘代物。Toceranib (SU11654) 是一种口服活性受体酪氨酸激酶 (RTK) 抑制剂,能有效抑制PDGFRVEGFRKit,抑制 PDGFRβ 和 Flk-1/KDR 的Ki值分别为 5 nM 和 6 nM。Toceranib 具有抗肿瘤和抗血管生成活性,用于犬肥大细胞肿瘤的研究。
生物活性

Toceranib-d8 (SU11654-d8) is the deuterium labeled Toceranib. Toceranib (SU11654) is an orally active receptor tyrosine kinase (RTK) inhibitor, and it potently inhibitsPDGFR,VEGFR, andKitwithKis of 5 and 6 nM forPDGFRβand Flk-1/KDR, respectively. Toceranib (SU11654) has antitumor and antiangiogenic activity, and used in the treatment of canine mast cell tumors[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

404.51

Formula

C22H17D8FN4O2

CAS 号

1795134-78-9

中文名称

托西尼布 d8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.