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Nintedanib-d3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nintedanib-d3图片
CAS NO:1624587-84-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
BIBF 1120-d3
产品介绍
Nintedanib-d3 (BIBF 1120-d3) 是 Nintedanib 的氘代物。Nintedanib (BIBF 1120) 是一种有效的三重血管激酶抑制剂,抑制VEGFR1/2/3FGFR1/2/3PDGFRα/βIC50值分别为 34 nM/13 nM/13 nM,69 nM/37 nM/108 nM 和 59 nM/65 nM。
生物活性

Nintedanib-d3 (BIBF 1120-d3) is the deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor forVEGFR1/2/3,FGFR1/2/3andPDGFRα/βwithIC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

542.64

Formula

C31H30D3N5O4

CAS 号

1624587-84-3

中文名称

尼达尼布 D3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.