CAS NO: | 136656-07-0 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
生物活性 | Timosaponin BII (Prototimosaponin A III) is a steroid saponin found in the rhizomes ofAnemarrhena asphodeloides. Timosaponin BII has neuronal protective, anti-inflammatory and antioxidant activities[1][2]. | ||||||||||||||||
体外研究 (In Vitro) | Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC50value of 15.5 μg/mL in the HL-60 cells[1]. | ||||||||||||||||
体内研究 (In Vivo) | Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time[2]. | ||||||||||||||||
分子量 | 921.07 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C45H76O19 | ||||||||||||||||
CAS 号 | 136656-07-0 | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: H2O : 100 mg/mL(108.57 mM;Need ultrasonic) DMSO : 100 mg/mL(108.57 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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