CAS NO: | 101246-66-6 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Phenserine ((-)-Eseroline phenylcarbamate) is a derivative of Physostigmine and is a potent, noncompetitive, long-acting and selectiveAChEinhibitor. Phenserine reducesβ-amyloid precursor protein (APP)andβ-amyloid peptide (Aβ)formation. Phenserine improves cognitive performance and attenuates the progression of Alzheimer's disease[1][2][3]. | ||||||||||||||||
IC50& Target | AChE; β-amyloid precursor protein; β-amyloid peptide[1] | ||||||||||||||||
体外研究 (In Vitro) | Phenserine (1-25 μM; 48 hours; CHO APP751SWcells) treatment CHO APP751SWcell shows 18.6% reduction in cells treated with 10 μM of Phenserine, while 25 μM concentration of Phenserine reduces APP level by 51.4%[2]. Western Blot Analysis[2]
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体内研究 (In Vivo) | Phenserine (1-4 mg/kg; intraperitoneal injection; for 4 days; male Fischer-344 rats) treatment improves learning when cholinergic function has been impaired in a spatial memory task[3].
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分子量 | 337.42 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C20H23N3O2 | ||||||||||||||||
CAS 号 | 101246-66-6 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 200 mg/mL(592.73 mM;Need ultrasonic) H2O :< 0.1 mg/mL (ultrasonic;warming;heat to 60℃)(insoluble) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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