Kuraridine is a prenylated flavonol extract from the roots of Sophora flavescens. Kuraridine has an inhibitory effect on cGMP specificphosphodiesterasetype 5 (PDE5) (IC₅₀=0.64 μM)^[1].

Kuraridine shows potent inhibitory activity (IC₅₀=0.64 μM) against cGMP PDE5 with 2.0- and 12.9-fold selectivity over PDE3 and PDE4, respectively^[1].
Kuraridine induces pronounced chloride inward currents in the absence of GABA. Thecurrents does not exceed 10% of the maximal I_GABA induced by a saturating GABA concentration (1 mM)^[2].
Kuraridine induces a concentration–response curves for I_GABA enhancement (EC₅₀=4.0±2.4 μM) inXenopus oocytes expressing GABA_A receptors composed of α1, β2, and γ2S subunits^[2].

438.51

Solid

C₂₆H₃₀O₆

34981-25-4

次苦参素；次苦参黄素

• Flavonoids
• Chalcones

• Phenols
• Polyphenols

• Plants
• Leguminosae
• Sophora flavescens

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 100 mg/mL(228.04 mM)

*"≥" means soluble, but saturation unknown.

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储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。