Kushenol A

立即咨询

Kushenol A

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

99217-63-7

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品名称

Leachianone E

产品介绍

Kushenol A (Leachianone E) 从苦参根中分离出来的。Kushenol A 是一种非竞争性酪氨酸酶 (tyrosinase) 抑制剂，可阻止 L-tyrosinase 转化为 L-DOPA，IC₅₀和K_i值分别为 1.1 μM 和 0.4 μM。Kushenol A 是一种类黄酮抗氧化剂，对 α-葡萄糖苷酶 (alpha-glucosidase) (IC₅₀: 45 μM;K_i: 6.8 μM) 和 β-淀粉酶 (beta-amylase) 具有抑制作用。Kushenol A 被认为是化妆品针对皮肤美白和衰老的潜在酶抑制剂。

生物活性

Kushenol A (Leachianone E) is isolated from the root ofSophora flavescent. Kushenol A is a non-competitivetyrosinaseinhibitor to block the conversion of L-tyrosine to L-DOPA, showsIC₅₀andK_ivalues of 1.1 μM and 0.4 μM, respectively^[1]. Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC₅₀: 45 μM;K_i: 6.8 μM) and β-amylase^[2]. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging^[1].

IC₅₀& Target

IC50: 1.1 μM (tyrosinase); 45 μM (alpha-glucosidase)^[1]^[2]

体外研究
(In Vitro)

Kushenol A (25 μM) exhibits a highly potent inhibitory activity on ABTS+ radical scavenging with an IC₅₀value of 9.7 ± 0.1 μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25 μM^[1].
Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC₅₀values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC₅₀value of 57.2 μg/ml for BEAS-2B cells^[3].

Cell Viability Assay^[3]

Cell Line:	NSCLC cell lines, A549 and NCI-H226 Normal human lung epithelial: BEAS-2B
Concentration:	0-60 μg/ml
Incubation Time:	24 hours
Result:	Exhibited considerable cytotoxic effects against NSCLC cells.

分子量

408.49

性状

Solid

Formula

C₂₅H₂₈O₅

CAS 号

99217-63-7

中文名称

苦参新醇A

结构分类

Flavonoids
Flavonones

Phenols
Polyphenols

来源

Plants
Leguminosae
Sophora flavescens

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 100 mg/mL(244.80 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.4480 mL	12.2402 mL	24.4804 mL
5 mM	0.4896 mL	2.4480 mL	4.8961 mL
10 mM	0.2448 mL	1.2240 mL	2.4480 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。