| CAS NO: | 136656-07-0 |
| 包装: | 20mg |
| 市场价: | 1943元 |
| Cas No. | 136656-07-0 |
| 别名 | 知母皂苷BII,Prototimosaponin A III |
| 分子式 | C45H76O19 |
| 分子量 | 920.5 |
| 溶解度 | ≥ 46mg/mL in EtOH with gentle warming |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Timosaponin BII is an antioxidant and an anti-inflammatory agent. Timosaponin BII is a steroidal glycoside separated from Zhi Mu, is found to have the inhibitory activity against the proliferation of HL-60 (leukemic), Hela (cervix), HepG2 and Bel-7402 (liver), HT-29 (colon), and MDA-MB-468 (breast) human carcinoma cell lines with an IC50 value of 15.5 μg/mL in the HL-60 cells[1]. Rat retinas in model group and vehicle control group manifest an apparent up-regulation of BACE1 expression. Meanwhile, the level of malonaldehyde (MDA), Aβ1-40 and β-CTF are increased. However, when comparing with the vehicle control group, the retinas in Timosaponin-BII treated group showed significantly less BACE1 and accumulated less Aβ1-40 or β-CTF. It also showed significantly decreased level of MDA and prolonged partial thromboplastin time[2]. References: |
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