Memantine

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Memantine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

19982-08-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

3,5-二甲基金刚胺

产品介绍

Memantine 是一种口服活性、非竞争性N-甲基-D-天冬氨酸受体(NMDAR)拮抗剂。美金刚可用于中重度阿尔茨海默病 (AD) 的研究。

生物活性

Memantine is an orally active, noncompetitive N-methyl-D-aspartate receptor(NMDAR)antagonist. Memantine can be used for the research of moderate-to-severe Alzheimer's disease (AD)^[1]^[2]^[3].

体内研究
(In Vivo)

Memantine (1, 5 and 10, 15 mg/kg; i.p.; daily for 15-20 days) significantly decreased the large LTP recorded in hippocampal slices from aged animals^[2].
Memantine (1-3 mg/kg; per os (p.o.)) for 14 days significantly improves depressive-like behaviors in olfactory bulbectomized (OBX) mice, as assessed using the tail-suspension and forced-swim tests^[3].

Animal Model:	Male Wistar rats^[2]
Dosage:	1, 5 and 10, 15 mg/kg
Administration:	i.p.; daily for 15-20 days
Result:	Significantly decreased the large LTP recorded in hippocampal slices from aged animals.

分子量

179.30

Formula

C₁₂H₂₁N

CAS 号

19982-08-2

中文名称

美金刚

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.