Pamapimod-d4 (Ro4402257-d4) is the deuterium labeled Pamapimod. Pamapimod (Ro4402257) is a potent, selective and orally activep38 MAPKinhibitor withIC₅₀s of 14 nM and 480 nM andK_is of 1.3 nM and 120 nM forp38αandp38β, respectively. Pamapimod has no activity againstp38δorp38γisoforms. Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment^[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

410.41

C₁₉H₁₆D₄F₂N₄O₄

1246814-57-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.