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Pamapimod-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pamapimod-d4图片
CAS NO:1246814-57-2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Pamapimod-d4 是 Pamapimod 的氘代物。Pamapimod (Ro4402257) 是一种有效的,选择性和口服活性的p38 MAPK抑制剂,对于p38αp38βIC50分别为 14 nM 和 480 nM,Ki分别为 1.3 nM 和 120 nM。Pamapimod 对 p38δ 或 p38γ 亚型没有活性。Pamapimod 可用于类风湿关节炎和其他自身免疫性疾病的研究。
生物活性

Pamapimod-d4 (Ro4402257-d4) is the deuterium labeled Pamapimod. Pamapimod (Ro4402257) is a potent, selective and orally activep38 MAPKinhibitor withIC50s of 14 nM and 480 nM andKis of 1.3 nM and 120 nM forp38αandp38β, respectively. Pamapimod has no activity againstp38δorp38γisoforms. Pamapimod has the potential for rheumatoid arthritis and other autoimmune diseases treatment[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

410.41

Formula

C19H16D4F2N4O4

CAS 号

1246814-57-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.