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Acetylastragaloside I
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Acetylastragaloside I图片
CAS NO:84687-47-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Acetylastragaloside I 是一种糖苷,可以从长小苞蔓黄芪的根中分离出。Acetylastragaloside I 是第一个具有显著的锥虫杀灭活性的环阿坦型三萜,对布氏罗得西亚锥虫美洲锥虫IC50值分别为 9.5 和 5.0 μg/mL。Acetylastragaloside I 可用于锥虫感染的研究。
生物活性

Acetylastragaloside I is a glycoside that can be isolated from the roots ofAstragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity withIC50values of 9.5 and 5.0 μg/mL forT. brucei rhodesienseandT. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosomeinfection[1].

IC50& Target

IC50: 9.5 μg/mL (T. brucei rhodesiense), 5.0 μg/mL (T. cruzi), >30 μg/mL (L. donovani), >20 μg/mL (P. falciparum), 24.2 μg/mL (L6 cells)[1]

体外研究
(In Vitro)

Acetylastragaloside I (0.123-90 μg/mL; 72-96 h) shows in vitro antiprotozoal activity toT. brucei rhodesiense,T. cruzi,L. donovaniandP. falciparumwith IC50values of 9.5, 5.0, >30 and >20 μg/mL, respectively[1].
Acetylastragaloside I (0.123-90 μg/mL; 72 h) exhibits cytotoxicity effects to rat skeletal myoblasts (L6) cells[1].

Cell Cytotoxicity Assay[1]

Cell Line:Rat skeletal myoblasts (L6) cell line
Concentration:0.123-90 μg/mL
Incubation Time:72 hours
Result:Showed cytotoxicity to L6 cells with an IC50value of 24.2 μg/mL.
分子量

911.08

Formula

C47H74O17

CAS 号

84687-47-8

结构分类
  • Others
来源
  • Plants
  • Leguminosae
  • Astragalus membranaceusvar. mongholicus (Bunge)P.K.Hsiao
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.