NMDAR/TRPM4-IN-2 free base

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1353979-43-7

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

NMDAR/TRPM4-IN-2 free base (化合物 8) 是一种有效的NMDAR/TRPM4相互作用界面抑制剂。NMDAR/TRPM4-IN-2 free base 具有神经保护活性。NMDAR/TRPM4-IN-2 free base 可预防 NMDA 诱导的海马神经元细胞死亡和线粒体功能障碍，其IC₅₀值为 2.1 μM。NMDAR/TRPM4-IN-2 free base 保护小鼠免受 MCAO 诱导的脑损伤和 NMDA 诱导的视网膜神经节细胞丢失。

生物活性

NMDAR/TRPM4-IN-2 free base (compound 8) is a potentNMDAR/TRPM4interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with anIC₅₀of 2.1 μM. NMDAR/TRPM4-IN-2 free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss^[1].

体外研究
(In Vitro)

NMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner^[1].
NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs^[1].

分子量

257.17

性状

Liquid

Formula

C₁₁H₁₇BrN₂

CAS 号

1353979-43-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL(388.85 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.8885 mL	19.4424 mL	38.8848 mL
5 mM	0.7777 mL	3.8885 mL	7.7770 mL
10 mM	0.3888 mL	1.9442 mL	3.8885 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。