Theaflavine-3,3'-digallate 是一种具有生物活性的红茶酚类物质，可用于研究肠道菌群组成调节作用。
| Cas No. | 33377-72-9 |
| 别名 | 茶黄素-3,3'-双没食子酸(TFBG) |
| 化学名 | (2S,3S)-2-(8-((2R,3R)-5,7-dihydroxy-3-((3,4,5-trihydroxybenzoyl)oxy)chroman-2-yl)-3,4,6-trihydroxy-5-oxo-5H-benzo[7]annulen-1-yl)-5,7-dihydroxychroman-3-yl 3,4,5-trihydroxybenzoate |
| Canonical SMILES | OC(C=C1O2)=CC(O)=C1C[C@](OC(C3=CC(O)=C(O)C(O)=C3)=O)([H])[C@@]2([H])C(C=C4O)=CC(C([C@@]5([H])[C@](OC(C6=CC(O)=C(O)C(O)=C6)=O)([H])CC7=C(O)C=C(O)C=C7O5)=CC(O)=C8O)=C8C4=O |
| 分子式 | C43H32O20 |
| 分子量 | 868.7 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 1. Theaflavin-3,3'-digallate is an inducer of oxidative stress and apoptosis.
2. A combination microbicide containing theaflavin-3,3'-digallate and lactic acid can reduce herpes simplex virus (HSV) transmission.
3. Theaflavin-3,3'-digallate may be useful chemoprevention agents for prostate cancer through suppressing the function of androgen and its receptor.
4. Theaflavin-3, 3'-digallate has strong antioxidant and antiangiogenic activities, it inhibits the tube formation of endothelial cells via decreased both MMP-2 and MMP-9 activities in vitro.
5. Theaflavin-3,3'-digallate may exert its anti-inflammatory and cancer chemopreventive actions by suppressing the activation of NFkappaB through inhibition of IkappaB kinase (IKK) activity.
6. Theaflavin-3,3'-digallate is a potent AMP-activated protein kinase (AMPK) activator with anti-adiposity activity in adipocytes, suggesting its potential application in functional foods and nutraceuticals for obesity management.
7. Theaflavin-3,3'-digallate can repress osteoclastogenesis and prevent wear debris-induced osteolysis via suppression of ERK pathway, it is a promising candidate for the treatment of osteoclast-related osteolytic diseases, such as wear debris-induced peri-implant osteolysis (PIO). |
m.cnreagent.com