Hydroxyzine, a benzodiazepineantihistamineagent, acts as an orally activehistamine H1-receptorand serotonin antagonist. Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder^[1].

Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min^[1].

Hydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats^[3].

374.90

C₂₁H₂₇ClN₂O₂

68-88-2

羟嗪

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.