Mapracorat is a novel non-steroidal selectiveglucocorticoid receptoragonist.

Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC₅₀value of approximately 0.2 nM.

Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas.

462.48

Solid

C₂₅H₂₆F₄N₂O₂

887375-26-0

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 33.6 mg/mL(72.65 mM)

*"≥" means soluble, but saturation unknown.

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