CAS NO: | 385800-16-8 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is aCOX-1andCOX-2inhibitor withIC50s of 8.72 and 5.15 μM, respectively in cell assay. | ||||||||||||||||
IC50& Target | IC50: 8.72 μM (COX-1), 5.15 μM (COX-2)[1] | ||||||||||||||||
体外研究 (In Vitro) | Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively[1]. | ||||||||||||||||
体内研究 (In Vivo) | Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation[2]. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM)[3]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 336.40 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C17H20O5S | ||||||||||||||||
CAS 号 | 385800-16-8 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(297.27 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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