Rofecoxib D5 (MK 966 D5) is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally activeCOX-2inhibitor, withIC₅₀s of 26 and 18 nM for humanCOX-2in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity forCOX-2over humanCOX-1(IC₅₀>50 μM in U937 cells and >15 μM in Chinese hamster ovary cells)^[1][2].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

319.39

C₁₇H₉D₅O₄S

544684-93-7

罗非考昔 d5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.