Synephrine hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

5985-28-4

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
100mg	电议
500mg	电议
1 g	电议
5 g	电议

产品名称

辛弗林盐酸盐
Oxedrine hydrochloride

产品介绍

Synephrine (Oxedrine) hydrochloride，一种生物碱，是一种来自Citrus aurantium的α-adrenergic和β-adrenergic激动剂。Synephrine hydrochloride 是一种拟交感神经化合物，可用于减肥。

生物活性

Synephrine (Oxedrine) hydrochloride, an alkaloid, is anα-adrenergicandβ-adrenergicagonist derived from theCitrus aurantium. Synephrine hydrochloride is a sympathomimetic compound and can be used for weight loss^[1]^[2].

IC₅₀& Target

β adrenergic receptor

体内研究
(In Vivo)

Synephrine (1 mg/kg; oral gavage; for 8 days; PVL and BDL rats) significantly ameliorates the hyperdynamic state in both PVL and BDL rats. The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index are significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance are enhanced by treatment of Synephrine^[2].

Animal Model:	Portal vein ligation (PVL) or bile duct ligation (BDL) rats^[2]
Dosage:	1 mg/kg per 12 hours
Administration:	Oral gavage; for 8 days
Result:	The portal venous pressure in PVL and BDL rats, portal tributary blood flow and cardiac index were significantly reduced, while mean arterial pressure and systemic as well as portal territory vascular resistance were enhanced.

分子量

203.67

性状

Solid

Formula

C₉H₁₄ClNO₂

CAS 号

5985-28-4

中文名称

辛弗林盐酸盐

结构分类

Alkaloids
Other Alkaloids

Phenols
Monophenols

来源

Plants
Rutaceae
Citrus × aurantiumLinnaeus

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

H₂O : ≥ 100 mg/mL(490.99 mM)

DMSO : ≥ 52 mg/mL(255.31 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	4.9099 mL	24.5495 mL	49.0990 mL
5 mM	0.9820 mL	4.9099 mL	9.8198 mL
10 mM	0.4910 mL	2.4550 mL	4.9099 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。